Spectinomycin as initial treatment for gonorrhea.
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منابع مشابه
Spectinomycin as initial treatment for gonorrhoea.
The prevalence of penicillinase producing Neisseria gonorrhoeae at this hospital increased exponentially from less than 0.5% in 1978 to 6.5% of all isolates in 1982. In January 1983 first line treatment for uncomplicated heterosexual anogenital gonorrhoea was therefore changed from ampicillin and probenecid to spectinomycin. This subsequently cured 95% of cases seen at the Praed Street Clinic. ...
متن کامل[Spectinomycin in the treatment of gonorrhea].
To the editor: We have read with interest the recent paper by Kubanova et al. in which they recommend the use of spectinomycin in case of difficulty to access ceftriaxone or in the presence of severe beta-lactam antimicrobial allergy [1]. Although we agree with most of the conclusions we would like to warn about the potential risks in cases of pharyngeal gonorrhoea. Spectinomycin is an aminogly...
متن کاملSpectinomycin disk zone diameter as a predictor of outcome in clinical treatment of gonorrhea.
The MICs for 41 Neisseria gonorrhoeae strains from patients receiving spectinomycin treatment were determined by the agar dilution method and compared with the zones of inhibition produced by disks containing 100 micrograms of spectinomycin. Our data demonstrated a good correlation between the two methods. Moreover, a zone of inhibition of less than or equal to 15 mm was a good predictor of cli...
متن کاملComparative study of cefoperazone and spectinomycin for treatment of uncomplicated gonorrhea in men.
Beta-lactamase-negative Neisseria gonorrhoeae infections were treated with single-dose cefoperazone (0.5 or 1.0 g) or spectinomycin (2.0 g). Anogenital infections were cured in 36 (83%) of 43 volunteers given 0.5 g of cefoperazone, 61 of 61 volunteers given 1.0 g of cefoperazone, and 99 of 100 volunteers given spectinomycin. The cefoperazone geometric mean MIC for 242 isolates was 0.028 microgr...
متن کاملComparison of spectinomycin hydrochloride and aqueous procaine penicillin G in the treatment of uncomplicated gonorrhea.
Men and women with uncomplicated gonorrhea were randomly assigned to receive aqueous procaine penicillin G (2,400,000 U for men; 2,400,000 U daily for 2 days for women) or spectinomycin hydrochloride (2.0 g for men; 4.0 g for women). Among men who returned for post-treatment evaluation within 10 days, treatment failures were noted among 16 (20.3%) of 79 men who received penicillin and 8 (9.5%) ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1984
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.289.6455.1383